I take a calcium channel blocker for my high blood pressure, and I have to avoid grapefruit. Grapefruit is a healthy food that is low in calories and high in vitamin C, antioxidants, and potassium. Terms of Use. Statins and grapefruit don't mix because components in grapefruit interfere with the way statins are broken down in the body. Interestingly, the interaction between grapefruit … The problem of toxic drug buildup similar to that caused by the interaction of statins and grapefruit can occur when people mix other drugs with fruits that contain bergamottin. Coincidentally, the enzymes that break down some statins also interact with chemicals in grapefruits. Unfortunately, a compound in grapefruit known as bergamottin interferes with the enzymes needed to metabolize certain statin drugs, including atorvastatin (Lipitor®), simvastatin (Zocor®), and lovastatin (Mevacor®). starting, changing or terminating any medical treatment. In all states except Tennessee, GoodRx is considered a marketer of prescription While grapefruit is a go-to healthy snack for many people, it contains a chemical called furanocoumarins which prevents enzymes in the body called CYP3A from breaking down certain types of statins. Is It OK to Combine Lisinopril and Grapefruit? What Are the Differences between Atorvastatin and Simvastatin Treatments. Problems can occur for those who are sensitive to statin medications or those who have kidney disease or other illnesses. In It is understandable that those who take statin drugs might want to add fresh grapefruit or grapefruit juice to their diets. That is because I take simvastatin to lower my cholesterol… In essence, grapefruit chemicals can attach to liver enzymes and affect how those enzymes process medications. What Are the Differences between Simvastatin and Lovastatin? Q. I love grapefruit, the whole fruit. When statin takers eat large amounts of grapefruit, the level of statins in their blood can increase, raising the possibility of side effects. Side effects of an interaction between statins and grapefruit include potentially fatal liver, kidney, and muscle damage. As a result, those statins stay active in the body for longer than expected. If the body can't properly metabolize cholesterol-lowering drugs, the drugs can build up in the patient's system, resulting in an overdose. What Are the Differences between Simvastatin and Pravastatin? The metabolism of some cholesterol drugs, such as pravastatin (Pravachol ®), fluvastatin (Lescol ®), and pitavastatin (Livalo ®), doesn't seem to be affected by grapefruit in the same way as other statin drugs. Not all statins have the same dangerous interaction with grapefruits. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). Even if you eat or drink grapefruit products many hours after taking your pills, the risk is still present. Please seek medical advice before Why Should I Not Combine Simvastatin and Grapefruit? its price comparisons. 7 Potential Side Effects of Albuterol Inhalers like ProAir, Ventolin, and Proventil, These 10 Prescription and OTC Medications Can Cause Heartburn and Hurt Your Esophagus. Grapefruit is a healthy food that is low in calories and high in vitamin C, antioxidants, and potassium. Evidence shows that only one instance of grapefruit or grapefruit product consumption can be enough to cause these drugs to build up in your system, and timing doesn't matter much either. Privacy Policy Statins and grapefruit don't mix because components in grapefruit interfere with the way statins are broken down in the body. If you take statin drugs for lowering cholesterol, it is a good idea to avoid grapefruit and grapefruit products. In the case of certain statins, grapefruit … Still, some medical professionals advise caution when combining the two anyway, and suggest that patients delay grapefruit consumption for several hours after taking their medication. Our livers contain enzymes that break down chemicals and medications, so they can be eliminated from the body. Why Do I Need Folic Acid When I’m Taking Methotrexate? GoodRx is not offering advice, recommending or endorsing any specific prescription If the body can't properly metabolize cholesterol … Copyright ©2020 GoodRx, Inc. Coincidentally, the enzymes that break down some statins also interact with chemicals in grapefruits. In reality, it’s only related to the 3 statins we mentioned above. So, it’s safe to continue enjoying your grapefruit with pravastatin (Pravachol), rosuvastatin (Crestor), fluvastatin (Lescol), and pitavastatin (Livalo). You may choose an alternative citrus beverage (such as orange juice). This information is for informational purposes only and of these rights holders. People taking statins should not ingest grapefruit. Grapefruit doesn’t affect other statins because they are metabolized by a different enzyme, CYP2C9. Cookie Preferences In fact, grapefruit can increase the risk for statin side effects by up to 5 times! Seville oranges are often included in fruit compotes and marmalades, and pomelos, or Chinese grapefruit, are a citrus fruit from southeast Asia that can be found in ethnic markets. FDA Approves Remdesivir (Veklury) to Treat COVID-19. In the case of certain statins, grapefruit chemicals prevent them from being broken down. Should patients avoid grapefruit juice consumption while taking widely used statins? If that enzyme is inhibited, the statin drugs stick around longer in your system and can cause more side effects and puts you … There is hope if you really enjoy grapefruit. Grapefruit juice contains compounds called furanocoumarins that … In essence, grapefruit chemicals can attach to liver enzymes and affect how those enzymes process medications. However, this is no problem for me. Side effects of an interaction between statins and grapefruit include potentially fatal liver, kidney, and muscle damage.

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